Sheba Medical Center’s Longevity Center has been making groundbreaking strides in aging research, revealing that most age-related health declines can be controlled. For the first time, researchers now have accurate tools to assess biological aging and predict health trajectories with remarkable precision.
Sheba’s pioneering SHARP (Sheba Healthy Aging Research Population) study has uncovered fascinating insights into the biological markers of aging. Tracking over 1,500 individuals aged 50 and above, the study has already identified key factors contributing to healthy aging. The results confirm that while 20% of aging is genetically determined, 80% is within our control, largely dependent on maintaining physical health.
“We are able to score our health in a way to predict health trajectories and know when someone will have a significant decline,” said Prof. Evelyn Bischof, Director of the Sheba Longevity Center. “Now we can correlate that score with biological aging.”

Health Factors That Slow Aging

Among those who maintained a biological age younger than their chronological age, researchers noted common traits like low abdominal fat, good cardiovascular fitness, high-quality sleep, and, interestingly, gender. Women were found to age more slowly than men in terms of biological markers. Additionally, women undergoing hormone replacement therapy showed improved health indicators, including better bone density and smaller waist circumferences.

Targeted Interventions to Enhance Longevity

The SHARP study is far from over, with further data collection planned for another year. Yet, these initial findings provide a promising outlook for future personalized interventions aimed at slowing the aging process. “We see again and again how people make an effort – but not always in the right direction. They exercise, take supplements – but in practice this does not always improve their health,” said Prof. Tzipi Strauss, Director of Sheba’s Neonatal department and Sheba’s Longevity Research Center. “Our research allows us to accurately assess people’s lifestyle and give recommendations that are based on science.” These findings mark a significant step toward longevity medicine aiming not just to extend life, but to improve the quality of the additional years that are added to our lifespan.

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