The review article sheds further light on chronic kidney disease, aiming to help doctors exercise more precise diagnosis and expand treatment options.

Sheba strives to remain at the forefront of medical research and is proud to announce the publication of a significant review article in the New England Journal of Medicine (NEJM), one of the most prestigious medical journals worldwide.

Genetic Insights into Chronic Kidney Disease

Chronic kidney disease (CKD) affects more than 800 million people worldwide, yet many of the causes of CKD are difficult to identify through traditional clinical diagnostics. Furthermore, it is estimated that 30-50% of CKD cases among children and 10-20% among adults can be explained through monogenic disorders. 

Penned by Prof. Asaf Vivante, Directorof the Department of Pediatrics B and the Genetic Kidney Disease Research Laboratory at Sheba, the article comprehensively examines the genetic factors contributing to chronic kidney disease.

Advancing CKD Care Through Genetic Diagnosis and Treatment

Providing physicians with a foundational understanding of the contribution of genetic diseases to CKD among children and adults, the review explores the latest advances in CKD genetic diagnosis and management and the contribution of variants that confer a substantial risk of progressive CKD. 

“Research into chronic kidney disease genetics has significantly advanced over the last few decades. Today physicians can provide a genetic-molecular diagnosis, establishing a precise cause for the disease and allowing personalized monitoring and treatment accompanied by genetic counseling,” said Prof. Asaf Vivante. “My hope is that physicians will use this review article to learn more about the current state of chronic kidney disease research and enable patients to access the latest advances in genetic-based diagnosis and treatment.”

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