A first-of-its-kind global study involving more than half of the new diagnoses of retinoblastoma across the world in 2017 revealed that survival rates vary significantly based on the economic status of their country. In high-income countries, nearly all children survive, while in low-income countries, just over half remain alive after three years. Advanced tumor stage, older age at diagnosis, and residence in low-income countries were associated with worse outcomes. Early diagnosis and swift intervention are crucial, especially in low-income countries, despite the availability of treatments worldwide. The study emphasizes the need for better awareness of retinoblastoma signs and improved access to prompt diagnosis and treatment, particularly in low-income and middle-income countries. It underscores the urgent need to address the disparities in treatment outcomes for children with retinoblastoma on a global scale.