In a new “Doctor on Call” video, Professor Itsik Levi, director of the HIV and STDs clinic at Sheba Medical Center, addresses common questions about HIV and AIDS and highlights why early testing is so important. He explains that being HIV-positive means living with the virus, while AIDS refers to a stage of severe immune system damage in which the body can no longer fight off everyday infections.

HIV vs. AIDS—Why Early Detection Matters

Prof. Levi emphasizes that his goal is to diagnose people when they are HIV-positive, before AIDS develops, so treatment can begin early and preserve immune function. A significant proportion of patients are still diagnosed only once they already have AIDS, often because they were not considered “at risk” due to stigma or misconceptions.
He notes that modern “combo tests” can detect HIV as early as seven weeks after exposure, with results available within hours, and encourages everyone to get tested—even those who feel well or do not see themselves as part of a traditional risk group, such as heterosexual or older adults.

Living Well with HIV

Thanks to advances in therapy, people living with HIV can now enjoy a normal lifespan and good quality of life, comparable to those who are HIV-negative.
Prof. Levi shares that some clinicians even find HIV easier to treat than common chronic conditions like hypertension or diabetes, underscoring how far treatment has progressed—though he stresses that avoiding infection remains the best option.

Person taking daily HIV medication as part of antiretroviral therapy

U=U: Undetectable Equals Untransmittable

 Prof. Levi highlights landmark “partner studies,” which showed that individuals on effective treatment who reach an undetectable viral load do not transmit HIV to their partners.
This principle, known as U=U (Undetectable = Untransmittable) and endorsed by major health authorities, not only protects others biologically but also reduces the emotional weight and stigma historically associated with HIV.

The Three Pillars of HIV Prevention

 HIV prevention, he explains, stands on three key pillars:

 

  • Treatment as prevention: Early diagnosis and consistent treatment prevent transmission to others, so people at risk should be tested at least once a year.
  • PrEP (pre-exposure prophylaxis): For those at higher risk, daily pills or long-acting injections can reduce infection risk by around 96–97%.
  • PEP (post-exposure prophylaxis): If a potential exposure occurs despite precautions, starting preventive medication as soon as possible afterward can reduce the chance of infection by about 90%.

Prof. Levi’s core message is clear: HIV is a manageable condition when detected early, and powerful tools now exist to protect both individuals and their partners. For more practical information and guidance, viewers are encouraged to watch the full “Doctor on Call” video with Professor Itsik Levi.

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