THE BRAIN CANCER
MOLECULAR MEDICINE LABORATORY (BCMML)

About

Activities

Collaborations
Donations

Leadership

Publications

Brain Cancer Molecular Medicine Laboratory

About

While recent decades saw great strides in the treatment of cancer, brain malignancies remain a major challenge. This is especially true when it comes to medulloblastoma, the most common type of malignant brain tumor in children, and glioblastoma, the most common type of malignant brain tumor in adults. With new therapies urgently needed, Sheba’s Brain Cancer Molecular Medicine Laboratory was established by Dr. Ruty Shai to accelerate translational research using groundbreaking molecular techniques that help discover genomic changes associated with brain cancer and identify both cancer biomarkers and therapeutic targets.

Breaking free from the constraints of conventional treatments, we forge a path towards more effective, personalized therapies capable of improving patient survival and quality of life.

Dr. Ruty Shai

Dr. Ruty Shai

BCMML Director

BCMML Activities

Cancer Biomarker Identification & Molecular Diagnostic Tool Development

Using large-scale genomic approaches and advanced technologies, the BCMML analyzes cancer genomes, searching for molecular markers (DNA, RNA, or protein abnormalities) that are part of brain cancer development. The molecular markers found are then studied in-depth to determine their impact: whether promoting tumor growth, increasing cancer’s ability to invade normal tissues, or suppressing the immune system. The results of this research are used to conduct real-time and liquid biopsies, as well as other diagnostic methods designed to facilitate early cancer and recurrence detection, along with accurate classification, which are critical for successful treatment.

Advanced Treatment Development

Leveraging a deep understanding of cancer’s genome and mechanism, the BCMML helps develop innovative brain cancer treatments based on molecular targeting of genes that slow or stop tumor growth and metastasis. By monitoring changes in biomarker expression during treatment, we allow clinicians to evaluate the effectiveness of therapeutic interventions and make timely adjustments, helping improve patient outcomes.

Brain Drug Delivery Facilitation

One of the main reasons current brain cancer treatments fall short is the difficulties associated with their administration and delivery to the brain. At the BCMML, we use nanomedicine to overcome this challenge, developing an efficient system for controlled delivery of drugs for brain cancer treatment. This is accomplished by oral drug delivery methods, which minimize damage to healthy tissues and enhance therapeutic effectiveness, as well as nanocapsules that serve as a platform to combine different therapeutic agents within a single delivery system.

Collaborations

BCMML physician-researchers work hand-in-hand with basic science investigators globally on innovative, groundbreaking studies designed to improve therapeutic approaches and outcomes.

Our notable partners include:

International Rare Diseases Research Consortium (IRDiRC), Diagnostics Scientific Committee

Children’s Brain Tumor Network (CBTN)

Children’s Hospital of Philadelphia (CHOP)

The Brain Cancer Molecular Medicine Laboratory Team

Dr. Ruty Shai

BCMML Director

A globally recognized brain cancer researcher, Dr. Ruty Shai completed her Ph.D. studies at the Hebrew University of Jerusalem before leaving for the U.S., where she underwent doctoral and postdoctoral training at the University of Southern California (USC) and UCLA. After four years as an Assistant Professor at USC, Dr. Shai moved back to Israel to lead the Brain Cancer Molecular Medicine Laboratory at Sheba Medical Center.

Under Dr. Shai’s leadership, the BCMML breaks ground in brain cancer research and treatment by integrating cutting-edge technologies and clinical expertise.

 [email protected]

Current and past students mentored by Dr. Shai:

Dikla Rogachevsky

 

Dikla Rogachevsky

PhD student

Shany Freedman

 

Shany Freedman

PhD student

Hadar Cohen

 

Hadar Cohen

M.Sc student

Hadar Cohen

 

Nicole Nabatkhorian

Arrow Program student

Aner Dafni

 

Aner Dafni

M.Sc student

Tatyana Pismenyuk

 

Tatyana Pismenyuk

M.Sc student

Hadar Cohen

 

Maria Jiryes

M.Sc student

Hadar Cohen

 

Guy Dumanis

Arrow Program student

Aner Dafni

 

Asaf Freed

Arrow student

Research & Publications

Research is a central part of Brain Cancer Medicine Molecular Laboratory activities and serves as a robust foundation for all of our efforts. Following are BCMLL scientific publications.

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